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    Find out why we chose to go with the "Superman of Caffeine" in Hardwire.

    Find out why we chose to go with the "Superman of Caffeine" in Hardwire.

      
    The Infinergy found in Hardwire, also known as Di-Caffeine Malate is a combination of the caffeine we all know and love, and malic acid. Infinergy contains approximately 75% caffeine and 25% malic acid by weight. Interestingly, long before this ingredient was used in pre-workout or cognitive enhancing supplements, Di-Caffeine Malate was actually used by Coca-Cola as a replacement stimulant after cocaine became banned for use in consumer products.

     
    Unfortunately, there is no clinical research to support that this type of caffeine has any real benefit over traditional caffeine. However, users report that the malic acid helps to ease the gastrointestinal distress commonly reported by users of normal caffeine. Likewise, malic acid plays an important role in the Kreb’s Cycle, which is the cellular process of energy production. As such, it is possible that Di-Caffeine Malate can sustain energy levels for longer periods of time without the typical crash most users experience from normal caffeine.
    Like other forms of caffeine, Di-Caffeine Malte helps to increase physical and cognitive performance, reduce fatigue, decrease perceived fatigue and increase metabolism (Goldstein et al. 2010). However, unlike other forms of caffeine, Di-Caffeine Malate is great to take at higher doses or any time during the day (I.e. before a workout or meeting), as one should not experience any digestive stress after ingestion.

     
    Although there is no current research to back any claims made about Di-Caffeine Malate, we cannot dismiss that caffeine and malic acid really do possess a lot of theoretical and synergistic opportunity for performance enhancement. In other words, the two together create a possible powerhouse of a supplement.

     

     
    - William Wallace PhD(c)
       Co-Founder of CreoDigm

     

     

     

    Reference

    Goldstein, E. R., Ziegenfuss, T., Kalman, D., Kreider, R., Campbell, B., Wilborn, C., ... & Wildman, R. (2010). International society of sports nutrition position stand: caffeine and performance. Journal of the International Society of Sports Nutrition7(1), 5.

    Do lion's hair actually have nootropic powers? Or are we confused on why one of our main ingredient is called Lion's Mane...

    Do lion's hair actually have nootropic powers? Or are we confused on why one of our main ingredient is called Lion's Mane...

      

     

    As of recently there has been an explosion of products containing medical /  ergogenic / Ayurvedic mushrooms. They can be found in tea, chocolate, and in raw-powdered form for supplemental consumption. Common mushrooms include Lion’s Mane, Cordyceps, and Reishi, but what is so special about these mushrooms? Let’s focus specifically on Lion’s Mane because it is one of the most popular for good reason. Lion’s Mane (Hericium erinaceus) or bearded tooth fungus is a mushroom found in Asia and has been used extensively in Chinese medicine. They look similar to a white toupee and grow on the wooded areas close to the base of trees.

     

    One of the most noted benefits of the compounds found in Lion’s Mane is their ability to increase neurotrophic growth factors such as Nerve Growth Factor (NGF). An increase in NGF in these studies showed to increase the signal transmitting organs in neurons (1,2). Which, in theory, could reduce cognitive decline and protect cognitive function throughout the lifespan. Lion’s Mane can also act as an antioxidant with the capabilities of reducing gastrointestinal related disorders (3). Furthermore, Lion’s Mane has the ability to reduce markers of chronic inflammation associated with obesity, which have an effect on many long term health problems such as diabetes and cancer (4). Therefore, Lion’s Mane’s cognitive benefits may be three fold because it promotes the growth of neurological tissue used in memory and learning; improves digestive health impacting cognitive function; and reduces whole body inflammation (4).

     

    The many benefits of Lion’s Mane support its use in Mainframe. Its ability to repair old brain cells and grow new cells works synergistically with Acteolin™, which acts as a free radical scavenger in the brain preventing neurological decline. Additionally, pairing Lion’s Mane with active nootropics such as Alpha-GPC, Sulbutiamine, and Bacopa Monnieri will not only maintain cognitive function, but enhance your ability to perform.

      

      

      

    - William Wallace PhD(c)
       Co-Founder of CreoDigm

      

      

      

    Citations
    1. Lai, P. L., Naidu, M., Sabaratnam, V., Wong, K. H., David, R. P., Kuppusamy, U. R., ... & Malek, S. N. A. (2013). Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. International journal of medicinal mushrooms, 15(6).
    2. Wong, K. H., Sabaratnam, V., Naidu, M., & Keynes, R. (2007). Activity of aqueous extracts of lion's mane mushroom Hericium erinaceus (Bull.: Fr.) Pers.(Aphyllophoromycetideae) on the neural cell line NG108-15. International Journal of Medicinal Mushrooms, 9(1).
    3. Wong, J. Y., Abdulla, M. A., Raman, J., Phan, C. W., Kuppusamy, U. R., Golbabapour, S., & Sabaratnam, V. (2013). Gastroprotective effects of Lion’s Mane mushroom Hericium erinaceus (Bull.: Fr.) Pers.(Aphyllophoromycetideae) extract against ethanol-induced ulcer in rats. Evidence-Based Complementary and Alternative Medicine, 2013.
    4. Collins, S. M., Surette, M., & Bercik, P. (2012). The interplay between the intestinal microbiota and the brain. Nature Reviews Microbiology, 10(11), 735.

    The solution to caffeine tolerance!

    The solution to caffeine tolerance!

    Caffeine is the most widely used “drug” on the market. It can be found in coffee, energy drinks, supplements, and common foods such as chocolate. Although, it has many benefits including increasing cognitive performance, reducing fatigue, and aiding in athletic performance (1,2) However, frequent and excessive use of caffeine can have negative effects such as increasing anxiety (2,3). What if there was an alternative to caffeine? You’re in luck because the supplement Theacrine (trade name Teacrine®) is proving to be a great substitute to frequent caffeine consumption.

    Theacrine is a caffeine derivative obtained from the Chinese Kucha Tea Leaf. In short, the caffeine made in the Kucha tea is metabolized into theacrine, therefore it is a natural ingredient. Similarly to caffeine, theacrine has been shown to have analgesic benefits by reducing perceived pain (4). There is also evidence suggesting theacrine can be a potent antioxidant, but this needs to be explored more in humans (5). Although, one of the most noted benefits of theacrine is its anti-apoptogenic properties. Simply speaking, unlike caffeine, you do not adapt to frequent use of theacrine (6). Therefore, if it were to be used every day, the cognitive affects would be the same every time.

    Theacrine functions via antagonizing adenosine receptors in the brain to increase wakefulness and alertness. The function of antagonizing adenosine receptors is one of the mechanisms as to why caffeine increases alertness (7). Therefore, theacrine functions as caffeine would but, as discussed earlier, has no adaptive properties. Among the cognitive research related to theacrine, many studies support its ability to increase mood, energy, attentiveness and focus. Teacrine® is found in the product Mainframe and Hardwire because it works synergistically with the other ingredients to effectively promote a cognitive boost.

     

    - William Wallace PhD(c)
       Co-Founder of CreoDigm

    Citations

     

    1. Smith, A. (2002). Effects of caffeine on human behavior. Food and chemical toxicology40(9), 1243-1255.

     

    1. Stuart, G. R., Hopkins, W. G., Cook, C., & Cairns, S. P. (2005). Multiple effects of caffeine on simulated high-intensity team-sport performance. Medicine and science in sports and exercise37(11), 1998.

     

    1. Nawrot, P., Jordan, S., Eastwood, J., Rotstein, J., Hugenholtz, A., & Feeley, M. (2003). Effects of caffeine on human health. Food Additives & Contaminants20(1), 1-30.

     

    1. Wang, Y., Yang, X., Zheng, X., Li, J., Ye, C., & Song, X. (2010). Theacrine, a purine alkaloid with anti-inflammatory and analgesic activities. Fitoterapia, 81(6), 627-631.

     

    1. Li, W. X., Li, Y. F., Zhai, Y. J., Chen, W. M., Kurihara, H., & He, R. R. (2013). Theacrine, a purine alkaloid obtained from Camellia assamica var. kucha, attenuates restraint stress-provoked liver damage in mice. Journal of agricultural and food chemistry, 61(26), 6328-6335.

     

    1. Taylor, L., Mumford, P., Roberts, M., Hayward, S., Mullins, J., Urbina, S., & Wilborn, C. (2016). Safety of TeaCrine®, a non-habituating, naturally-occurring purine alkaloid over eight weeks of continuous use. Journal of the International Society of Sports Nutrition, 13(1), 2.

     

    1. Feduccia, A. A., Wang, Y., Simms, J. A., Henry, Y. Y., Li, R., Bjeldanes, L., ... & Bartlett, S. E. (2012). Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: involvement of adenosine and dopamine receptors. Pharmacology Biochemistry and Behavior102(2), 241-248.

     

     

     

     

     

    Is Lack Of Sleep Slowly Killing Us?

    Is Lack Of Sleep Slowly Killing Us?

    We live in an age of over-stimulation. More people are consuming multiple cups of coffee, energy drinks and popping pharmaceutical stimulants (I.e. Adderall, Modafinil, Ritalin, etc.) than ever before. What’s more is that Facebook, Twitter and Instagram consume most of our free time. For every like, comment or follow we see on our Instagram pages, our brain is exposed to a pleasure response that results in excitation of the central nervous system. We are constantly being bombarded by excitation signals from the outside world, and the rate at which we are receiving them is taking a toll on our health. An over stimulated nervous system is causing more adults than ever to report severe insomnia and inability to get a quality night of sleep. Unfortunately, poor sleeping habits are also associated with obesity, diabetes, cardiovascular disease, reduced cognitive function and decline in immune health. Many of us are in desperate need of toning down our nervous system and repairing our cognitive function. This begins with a good night of sleep and is the very reason Defrag was developed.
     
    Relaxing Neuro Support Complex
    Gama Aminobutyric Acid (Gaba) is considered to be the chief inhibitory neurotransmitter within the body. In other words, it is our body’s major anxiety and stress reliever. Most research says that oral Gaba supplementation is ineffective, as it does not cross the blood-brain barrier (Galloway et al. 2000). However, when dosed high enough, users report Gaba’s ability to help them calm down and sleep better. Dosed at 1000mg, the Gaba in Defrag will do the trick.
    Griffonia Simplicifolia Seed Extract (98%) contains a precursor to another one of our brain’s primary anti-anxiety and inhibitory chemicals, 5-HTP. 5-HTP is necessary for the body to produce Serotonin (Carnevale et al. 2011). Elevating levels of Serotonin should help to relieve stressful thoughts, promote feelings of well-being and help us sleep through the night.
    L-Theanine is one of the most versatile compounds we consider to be “nootropics”. L-Theanine increases the production of Gaba and Dopamine in the brain simultaneously (Juneja et al. 1999). Taken before bed, it provides a very subtle relaxation and works synergistically with the rest of the ingredients in Defrag
    Melatonin helps to regulate our hormones and maintain the natural circadian rhythm in the body. Our bodies should naturally create Melatonin. However, stress, aging, late-night light exposure and other medications can interfere with our ability to make it (Lewy et al. 1980). Therefore, supplementing with it is one of the most useful ways to make sure we get to sleep and stay asleep.
     
    Anti-Stress & Adaptogen Complex
    Reishi Mushroom Powder (Ganoderma Lucidum) is one of the more popular mushroom subtypes used for medicinal purposes. Traditionally, Reishi has been used to strengthen the immune system and prevent viral infections (Jin et al. 2012). The 500mg of Reishi found in Defrag is a much-needed boost for weakened immune systems whilst we sleep.
    Ashwagandha Root Extract (Withania Somnifera) or “Indian Ginseng” is quickly becoming one of the more regularly used anxiety reducing and longevity promoting supplements on the market. This plant extract has potent antioxidant properties and has been shown to calm and relax both mind and body by reducing cortisol levels (Agarwal et al. 1999). With effects seen in as little as 200mg, the 300mg found in Defrag will provide you with all this extract has to offer.
    Phosphatidyl Serine (20%) is a type of fat that makes up between 2-10% of all the fat cells within our bodies (Pepeu, Pepeu & Amaducci. 1996). At least half of this is located in the cells of the brain, making it a crucially important ingredient for brain function. Supplementation with Phosphatidyl Serine before sleep will rejuvenate neurons in the brain, allowing them to send messages at a faster rate.
    Rutaecarpine (Evodia Rutaecarpa) is a plant of which the berries have been used in Chinese medicine for centuries. Its primary benefits affect gut health and reduce pain. Rutaecarpine may help to burn fat, though this needs to be investigated by further research. Interestingly, it greatly increases caffeine metabolism rates (Noh et al. 2011). Therefore, “detoxing” the body of caffeine’s stimulatory effects and preparing us for sleep.
     
    Essential Mineral Complex
    Magnesium plays hundreds of different roles in the human body. Magnesium L-Threonate was developed by researchers looking to enhance the bioavailability of supplemental Magnesium. This form of Magnesium has the highest absorption rates and produces positive cognitive enhancement than any other form (Slutsky et al. 2010). It is no surprise that Method Performance chose L-Threonate for Defrag.
    Small amounts of Zinc are necessary for optimal brain health and cognitive function and hormone balance in both men and women. In addition, Zinc is an essential nutrient that aids in regulating our sleep-wake cycles. (Ren et al. 2017).
     
    Optical Support Complex
    The Marigold Flower Extract (Lutein 5%) used in Defrag has strong antioxidant properties which boost the function of the immune and digestive systems. However, its uses in Defrag support eye health, as it has been shown to reduce ocular inflammation (Bernstein et al. 2001).
    Zeaxanthin (5%) is commonly used alongside lutein (found in Defrag) for preserving eye health. This substance helps protect the eyes from light-induced damage and is protective against age-related eye health degradation (Roberts et al. 2009).
     
     
    - William Wallace PhD(c)
       Co-Founder of CreoDigm
      
       
      
      
      
     
     
      
    References
    Agarwal, R., Diwanay, S., Patki, P., & Patwardhan, B. (1999). Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation. Journal of Ethnopharmacology, 67(1), 27-35.
    Bernstein, P. S., Khachik, F., Carvalho, L. S., Muir, G. J., Zhao, D. Y., & Katz, N. B. (2001). Identification and quantitation of carotenoids and their metabolites in the tissues of the human eye. Experimental eye research, 72(3), 215-223.
    Carnevale, G., Di Viesti, V., Zavatti, M., & Zanoli, P. (2011). Anxiolytic-like effect of Griffonia simplicifolia Baill. seed extract in rats. Phytomedicine, 18(10), 848-851.
    Galloway, G. P., Frederick-Osborne, S. L., Seymour, R., Contini, S. E., & Smith, D. E. (2000). Abuse and therapeutic potential of gamma-hydroxybutyric acid. Alcohol, 20(3), 263-269.
    Jin, X., Ruiz Beguerie, J., Sze, D. M., & Chan, G. C. (2012). Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane Database Syst Rev, 6.
    Juneja, L. R., Chu, D. C., Okubo, T., Nagato, Y., & Yokogoshi, H. (1999). L-theanine—a unique amino acid of green tea and its relaxation effect in humans. Trends in Food Science & Technology, 10(6-7), 199-204.
    Lewy, A. J., Wehr, T. A., Goodwin, F. K., Newsome, D. A., & Markey, S. P. (1980). Light suppresses melatonin secretion in humans. Science, 210(4475), 1267-1269.
    Noh, K., Seo, Y. M., Lee, S. K., Bista, S. R., Kang, M. J., Jahng, Y., ... & Jeong, T. C. (2011). Effects of rutaecarpine on the metabolism and urinary excretion of caffeine in rats. Archives of pharmacal research, 34(1), 119-125.
    Pepeu, G., Pepeu, I. M., & Amaducci, L. (1996). A review of phosphatidylserine pharmacological and clinical effects. Is phosphatidylserine a drug for the ageing brain? Pharmacological Research, 33(2), 73-80.
    Ren, L., Pour, M. D., Majdi, S., Li, X., Malmberg, P., & Ewing, A. G. (2017). Zinc Regulates Chemical‐Transmitter Storage in Nanometer Vesicles and Exocytosis Dynamics as Measured by Amperometry. Angewandte Chemie International Edition, 56(18), 4970-4975.
    Roberts, R. L., Green, J., & Lewis, B. (2009). Lutein and zeaxanthin in eye and skin health. Clinics in Dermatology, 27(2), 195-201.
    Slutsky, I., Abumaria, N., Wu, L. J., Huang, C., Zhang, L., Li, B., ... & Tonegawa, S. (2010). Enhancement of learning and memory by elevating brain magnesium. Neuron, 65(2), 165-177.

    Are you a "STIM JUNKIE?" Upgrade your caffeine source.

    Are you a "STIM JUNKIE?" Upgrade your caffeine source.
    Method Performance realizes that there is a need amongst these groups of people for supplements that provide lasting energy, promote enhanced cognitive ability and even have the potential to repair damage that we’ve sustained to our brain and body over time. That is why Hardwire was developed.

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